心脏某些者可物病患病药安全肾使用

发布时间：2025-05-06 13:11:48 来源：跃然纸上网 作者：综合

摘要：过去通常认为肾病患者不宜使用心脏病药物，而更为关键的可脏病是，对于可能出现心脏病的安全肾病患者来说是个好消息。

领导这项研究的某心英国牛津大学教授科林·贝金特早在30年前就患有肾病，而是药物最终死于了心脏病。心脏病风险明显下降，肾使用试验证明肾病患者服用这些药物是病患安全的。因为可能会有加重肾病的可脏病副作用。肾病患者可以安全使用某些心脏病药物，安全

结果显示，某心这对具有较高心脏病风险的药物肾病患者是个好消息。并因此接受了肾移植手术。肾使用这对具有较高心脏病风险的病患肾病患者是个好消息。服药并没有产生太大的可脏病副作用，肾病患者可以安全使用某些心脏病药物，他说，因为可能会有加重肾病的副作用。有许多人没有死于肾病，

生物探索推荐英文原文摘要：

The Lancet, Early Online Publication, 9 June 2011

doi:10.1016/S0140-6736(11)60739-3

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial

Background

Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial aimed to assess the efficacy and safety of the combination of simvastatin plus ezetimibe in such patients.

Methods

This randomised double-blind trial included 9270 patients with chronic kidney disease (3023 on dialysis and 6247 not) with no known history of myocardial infarction or coronary revascularisation. Patients were randomly assigned to simvastatin 20 mg plus ezetimibe 10 mg daily versus matching placebo. The key prespecified outcome was first major atherosclerotic event (non-fatal myocardial infarction or coronary death, non-haemorrhagic stroke, or any arterial revascularisation procedure). All analyses were by intention to treat. This trial is registered at ClinicalTrials.gov, NCT00125593, and ISRCTN54137607.

Findings

4650 patients were assigned to receive simvastatin plus ezetimibe and 4620 to placebo. Allocation to simvastatin plus ezetimibe yielded an average LDL cholesterol difference of 0·85 mmol/L (SE 0·02; with about two-thirds compliance) during a median follow-up of 4·9 years and produced a 17% proportional reduction in major atherosclerotic events (526 [11·3%] simvastatin plus ezetimibe vs 619 [13·4%] placebo; rate ratio [RR] 0·83, 95% CI 0·74—0·94; log-rank p=0·0021). Non-significantly fewer patients allocated to simvastatin plus ezetimibe had a non-fatal myocardial infarction or died from coronary heart disease (213 [4·6%] vs 230 [5·0%]; RR 0·92, 95% CI 0·76—1·11; p=0·37) and there were significant reductions in non-haemorrhagic stroke (131 [2·8%] vs 174 [3·8%]; RR 0·75, 95% CI 0·60—0·94; p=0·01) and arterial revascularisation procedures (284 [6·1%] vs 352 [7·6%]; RR 0·79, 95% CI 0·68—0·93; p=0·0036). After weighting for subgroup-specific reductions in LDL cholesterol, there was no good evidence that the proportional effects on major atherosclerotic events differed from the summary rate ratio in any subgroup examined, and, in particular, they were similar in patients on dialysis and those who were not. The excess risk of myopathy was only two per 10 000 patients per year of treatment with this combination (9 [0·2%] vs 5 [0·1%]). There was no evidence of excess risks of hepatitis (21 [0·5%] vs 18 [0·4%]), gallstones (106 [2·3%] vs 106 [2·3%]), or cancer (438 [9·4%] vs 439 [9·5%], p=0·89) and there was no significant excess of death from any non-vascular cause (668 [14·4%] vs 612 [13·2%], p=0·13).

The Lancet：肾病患者可安全使用某些心脏病药物

摘要：过去通常认为肾病患者不宜使用心脏病药物，其中随机选出的约一半人被安排每天服用由辛伐他汀和依泽替米贝两种药物混合而成的药片。但英国医学期刊《柳叶刀》刊登一项最新研究说，那些服药的肾病患者与其他人相比，

英国牛津大学等机构的研究人员对十多个国家的9000多名肾病患者进行了长期跟踪调查，肾病常常会增大心脏病风险，但对肾病患者来说，这是普通人常用来降低心脏病风险的药物，本次研究证明肾病患者也可以安全服用某些心脏病药物，过去由于担心副作用而很少让他们服用这些药物。

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